Abstract
Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2 immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves.
MeSH terms
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Aged
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Aged, 80 and over
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Amyloid Neuropathies / physiopathology*
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Amyloidosis / physiopathology
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Autonomic Nervous System / physiopathology*
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Cholinergic Fibers / physiology
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Disease Progression
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Female
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Humans
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Male
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Middle Aged
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Muscle Hypertonia / physiopathology
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Neurons, Afferent / physiology
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Prealbumin / physiology
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Retrospective Studies
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Urinary Bladder / innervation
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Urinary Incontinence / physiopathology
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Urinary Retention / physiopathology
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Urinary Tract / physiopathology*
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Urodynamics / physiology*