Aggregation-induced folding of a de novo designed polypeptide immobilized on gold nanoparticles

J Am Chem Soc. 2006 Feb 22;128(7):2194-5. doi: 10.1021/ja057056j.

Abstract

This communication reports the first steps in the construction of a novel, nanoparticle-based hybrid material for biomimetic and biosensor applications. Gold nanoparticles were modified with synthetic polypeptides to enable control of the particle aggregation state in a switchable manner, and particle aggregation was, in turn, found to induce folding of the immobilized peptides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Dimerization
  • Glutamic Acid / chemistry
  • Gold / chemistry*
  • Hydrogen-Ion Concentration
  • Models, Molecular
  • Molecular Sequence Data
  • Nanostructures / chemistry*
  • Peptides / chemistry*
  • Protein Folding

Substances

  • Peptides
  • Glutamic Acid
  • Gold