Caged gene-inducer spatially and temporally controls gene expression and plant development in transgenic Arabidopsis plant

Bioorg Med Chem Lett. 2006 May 1;16(9):2470-4. doi: 10.1016/j.bmcl.2006.01.103. Epub 2006 Feb 9.

Abstract

Two new types of caged gene-inducers, caged 17beta-estradiol and caged dexamethazone, were synthesized. Caged gene-inducers were applied to transgenic Arabidopsis plants carrying a steroid hormone-inducible transactivation system. Light uncaged caged gene-inducers and controlled spatial and temporal expression of transgene in the transgenic plant. Furthermore, caged gene-inducers enabled the control of root development by light.

MeSH terms

  • Arabidopsis / genetics*
  • Arabidopsis / growth & development*
  • Arabidopsis / radiation effects
  • Dexamethasone / chemical synthesis
  • Dexamethasone / chemistry
  • Dexamethasone / pharmacology*
  • Estradiol / chemical synthesis
  • Estradiol / chemistry
  • Estradiol / pharmacology*
  • Gene Expression Regulation, Developmental / drug effects*
  • Gene Expression Regulation, Developmental / radiation effects
  • Gene Expression Regulation, Plant / drug effects*
  • Gene Expression Regulation, Plant / radiation effects
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry
  • Imidazoles / pharmacology*
  • Molecular Structure
  • Nitro Compounds / chemical synthesis
  • Nitro Compounds / chemistry
  • Nitro Compounds / pharmacology*
  • Plants, Genetically Modified / drug effects
  • Plants, Genetically Modified / radiation effects
  • Structure-Activity Relationship
  • Ultraviolet Rays

Substances

  • 1-(2-nitrophenyl)ethylcarbonyl imidazole
  • Imidazoles
  • Nitro Compounds
  • Estradiol
  • Dexamethasone