Abstract
We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / therapeutic use*
-
Azithromycin
-
Clarithromycin
-
Erythromycin / analogs & derivatives
-
Erythromycin / therapeutic use
-
Leprosy / drug therapy*
-
Leprosy / microbiology
-
Mice
-
Mice, Inbred BALB C
-
Mycobacterium leprae / drug effects
-
Roxithromycin / therapeutic use
Substances
-
Anti-Bacterial Agents
-
Roxithromycin
-
Erythromycin
-
Azithromycin
-
Clarithromycin