The role of IL-10 in crossregulation of TH1 and TH2 responses

Immunol Today. 1991 Mar;12(3):A49-53. doi: 10.1016/S0167-5699(05)80015-5.

Abstract

The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibody Formation*
  • Cell Communication
  • Cytokines / metabolism
  • Herpesvirus 4, Human / genetics
  • Humans
  • Hypersensitivity, Delayed / immunology*
  • Hypersensitivity, Delayed / pathology
  • Interleukin-10
  • Interleukins / physiology*
  • Lymphocyte Activation
  • Lymphocyte Cooperation*
  • Mice
  • Parasitic Diseases / immunology
  • Sequence Homology, Nucleic Acid
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism

Substances

  • Antibodies, Monoclonal
  • Cytokines
  • Interleukins
  • Interleukin-10