Tangle diseases and the tau haplotypes

Alzheimer Dis Assoc Disord. 2006 Jan-Mar;20(1):60-2. doi: 10.1097/01.wad.0000201853.54493.d8.

Abstract

Neurofibrillary tangles are found in many neurologic diseases. Here we review the unusual characteristics of the MAPT locus, which shows genetic association with many of these diseases and in Caucasian populations, is the largest stretch of linkage disequilibrium in the genome. We discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at MAPT in the etiology of tauopathies.

MeSH terms

  • Alzheimer Disease / genetics*
  • Animals
  • Chromosome Inversion / genetics*
  • Chromosome Mapping*
  • DNA, Complementary / genetics
  • Disease Progression
  • Gene Duplication
  • Genetic Variation / genetics
  • Haplotypes*
  • Heredodegenerative Disorders, Nervous System / genetics*
  • Humans
  • Linkage Disequilibrium
  • Nerve Tissue Proteins / genetics*
  • Neurofibrillary Tangles / genetics*
  • Pan troglodytes
  • Sequence Analysis, DNA
  • Species Specificity
  • Supranuclear Palsy, Progressive / genetics*
  • Tauopathies / genetics*
  • tau Proteins

Substances

  • DNA, Complementary
  • MAPT protein, human
  • Nerve Tissue Proteins
  • tau Proteins