A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei

David M Waag; Michael J McCluskie; Ningli Zhang; Arthur M Krieg

doi:10.1128/IAI.74.3.1944-1948.2006

A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei

Infect Immun. 2006 Mar;74(3):1944-8. doi: 10.1128/IAI.74.3.1944-1948.2006.

Authors

David M Waag¹, Michael J McCluskie, Ningli Zhang, Arthur M Krieg

Affiliation

¹ Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011, USA. [email protected]

Abstract

Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.

MeSH terms

Adjuvants, Immunologic / administration & dosage*
Adjuvants, Immunologic / pharmacology
Administration, Inhalation
Animals
Bacteremia / immunology
Bacteremia / prevention & control*
Burkholderia mallei*
Glanders / immunology
Glanders / prevention & control*
Mice
Mice, Inbred BALB C
Oligodeoxyribonucleotides / administration & dosage*
Oligodeoxyribonucleotides / immunology

Substances

Adjuvants, Immunologic
CPG-oligonucleotide
Oligodeoxyribonucleotides