Abstract
This study examined whether abnormal responses to neurobiological challenge tests in borderline personality disorder (BPD) are related to a history of childhood sexual abuse (CSA). We compared patients meeting BPD criteria (n=24), with and without histories of CSA, with normal controls (n=12) on the results of challenges with meta-chlorphenylpiperazine (m-CPP), pyridostigmine and clonidine. No differences were found between abused and non-abused patients with BPD. These results do not support the hypothesis that CSA is directly related to neurobiological abnormalities in BPD.
MeSH terms
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Adolescent
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Adrenergic alpha-Agonists* / pharmacology
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Adult
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Borderline Personality Disorder / diagnosis*
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Borderline Personality Disorder / epidemiology*
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Borderline Personality Disorder / psychology
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Child
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Child Abuse, Sexual / diagnosis
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Child Abuse, Sexual / psychology
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Child Abuse, Sexual / statistics & numerical data*
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Cholinesterase Inhibitors* / pharmacology
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Clonidine* / pharmacology
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Female
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Humans
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Middle Aged
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Piperazines* / pharmacology
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Prolactin / metabolism
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Pyridostigmine Bromide* / pharmacology
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Serotonin Receptor Agonists* / pharmacology
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Stress Disorders, Post-Traumatic / diagnosis
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Stress Disorders, Post-Traumatic / epidemiology
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Stress Disorders, Post-Traumatic / psychology
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Surveys and Questionnaires
Substances
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Adrenergic alpha-Agonists
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Cholinesterase Inhibitors
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Piperazines
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Serotonin Receptor Agonists
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Prolactin
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Pyridostigmine Bromide
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Clonidine
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1-(3-chlorophenyl)piperazine