Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents

Atul Kumar; S R Pathak; Pervez Ahmad; S Ray; P Tewari; A K Srivastava

doi:10.1016/j.bmcl.2006.02.013

Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents

Bioorg Med Chem Lett. 2006 May 15;16(10):2719-23. doi: 10.1016/j.bmcl.2006.02.013. Epub 2006 Feb 24.

Authors

Atul Kumar¹, S R Pathak, Pervez Ahmad, S Ray, P Tewari, A K Srivastava

Affiliation

¹ Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. [email protected]

PMID: 16500101
DOI: 10.1016/j.bmcl.2006.02.013

Abstract

A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague-Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / analysis
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / drug therapy
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology*
Hypoglycemic Agents / therapeutic use
Male
Naphthalenes / chemistry
Naphthalenes / pharmacology*
Naphthalenes / therapeutic use
Rats
Rats, Sprague-Dawley
Streptozocin

Substances

Blood Glucose
Hypoglycemic Agents
Naphthalenes
naphthalene
Streptozocin