Abstract
Most patients with small-cell lung cancer usually relapse within 1 to 2 years. Relapses after a 5-year disease-free interval occur extremely rarely. This report describes a patient with limited-stage small-cell lung cancer who had achieved a complete response to combination chemotherapy followed by chest irradiation but developed small-cell lung cancer 9.4 years after the beginning of therapy. Small-cell lung cancer recurred in the same side of the lung, in the mediastinal nodes, and in the liver. The pattern of development of small-cell lung cancer suggests that the patient had a relapse rather than a metachronous lung cancer. To our knowledge, this is the second-latest relapse of small-cell lung cancer in the literature.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bronchoscopy
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Carcinoma, Small Cell / diagnostic imaging*
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Carcinoma, Small Cell / mortality
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Carcinoma, Small Cell / therapy
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Female
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Humans
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Lung Neoplasms / diagnostic imaging*
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Lung Neoplasms / mortality
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Lung Neoplasms / therapy
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Male
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Middle Aged
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Neoplasm Recurrence, Local
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Nimustine / administration & dosage
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Procarbazine / administration & dosage
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Radiography
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Radiotherapy / standards
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Survival Rate
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Vincristine / administration & dosage
Substances
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Nimustine
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Procarbazine
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Vincristine
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Doxorubicin
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Cyclophosphamide