Glycoconjugates of gadolinium complexes for MRI applications

Chem Commun (Camb). 2006 Mar 14:(10):1064-6. doi: 10.1039/b517997a. Epub 2006 Feb 8.

Abstract

Examples of C-4 symmetric, medium MW conjugates incorporating 12 glucose or galactose groups linked via four dendritic wedges to a central Gd complex have been characterised; their enhanced relaxivity is interpreted in terms of effective motional coupling and large contributions from second sphere water molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gadolinium / chemistry*
  • Glucose / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Molecular Structure

Substances

  • Gadolinium
  • Glucose