Abstract
Two hundred forty-one healthy infants were enrolled in an open randomised controlled study of three doses of DTaP-IPV-Hib (Group 1) or DTwP/Hib+OPV (Group 2) at 2, 3 and 4 months of age given concurrently with a meningitis C conjugate vaccine. After each dose, local reactions (any grade) were less common in Group 1 than Group 2 (p<0.03). Axillary temperature >37.5 degrees C, decreased feeding, reduced activity, irritability and crying in the week after vaccination were also less common in Group 1 than Group 2 (p<0.05 for each symptom, all doses combined). Severe local reactions and systemic symptoms were uncommon and occurred equally in both groups. The pentavalent DTaP-IPV-Hib vaccine was less reactogenic than the quadrivalent DTwP-Hib vaccine, as expected when changing from whole cell pertussis (wP) to an acellular pertussis (aP) component.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / adverse effects*
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Body Temperature
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Crying
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
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Feeding Behavior
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Female
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Humans
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Infant
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Irritable Mood
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Male
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Meningococcal Vaccines / administration & dosage*
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Motor Activity
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Poliovirus Vaccine, Inactivated
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Poliovirus Vaccine, Oral / administration & dosage
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Poliovirus Vaccine, Oral / adverse effects
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United Kingdom
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Vaccines, Acellular / administration & dosage
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Vaccines, Acellular / adverse effects*
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
Substances
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Bacterial Vaccines
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DT5aP-Hib-IPV vaccine
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Diphtheria-Tetanus-Pertussis Vaccine
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Meningococcal Vaccines
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Poliovirus Vaccine, Inactivated
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Poliovirus Vaccine, Oral
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Vaccines, Acellular
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Vaccines, Combined
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serogroup C meningococcal conjugate vaccine