Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity

Rainer Doffinger; Smita Y Patel; Dinakantha S Kumararatne

doi:10.1016/j.micinf.2005.10.028

Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity

Microbes Infect. 2006 Apr;8(4):1141-50. doi: 10.1016/j.micinf.2005.10.028. Epub 2006 Jan 19.

Authors

Rainer Doffinger¹, Smita Y Patel, Dinakantha S Kumararatne

Affiliation

¹ Department of Clinical Biochemistry and Immunology, Box 109, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK.

PMID: 16520078
DOI: 10.1016/j.micinf.2005.10.028

Abstract

This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.

Publication types

Review

MeSH terms

Animals
CD4-Positive T-Lymphocytes / immunology
Genetic Predisposition to Disease
Humans
Immunocompromised Host*
Immunologic Deficiency Syndromes / complications*
Interferon-gamma / immunology
Macrophages / immunology
Mycobacterium Infections / etiology
Mycobacterium Infections / genetics*
Mycobacterium Infections / immunology
Mycobacterium*

Substances

Interferon-gamma