Abstract
2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / therapeutic use
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Carcinoma, Squamous Cell / drug therapy
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Chemical Phenomena
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Chemistry
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Cytomegalovirus / drug effects
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / chemical synthesis
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Deoxycytidine / therapeutic use
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Deoxyuridine / analogs & derivatives*
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Deoxyuridine / chemical synthesis
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Deoxyuridine / pharmacology
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Deoxyuridine / therapeutic use
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Humans
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Leukemia L1210 / drug therapy
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Leukemia, T-Cell / drug therapy
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Mice
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Simplexvirus / drug effects
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Thionucleosides / chemical synthesis*
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Thionucleosides / therapeutic use
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Thiouridine / analogs & derivatives*
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Thiouridine / chemical synthesis
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Thiouridine / pharmacology
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Thiouridine / therapeutic use
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Thymidine / analogs & derivatives*
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Thymidine / chemical synthesis
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Thymidine / therapeutic use
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Antiviral Agents
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Thionucleosides
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Deoxycytidine
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2'-deoxy-4'-thiocytidine
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2'-deoxy-4'-thiouridine
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4'-thiothymidine
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Thiouridine
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Thymidine
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Deoxyuridine