Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are secondary adrenal androgens, mainly produced in the reticular layer as well as in the gonads and in the central nervous system. These prohormones influence many functions in human organism, but their most important effect seems to slow down the ageing process. It is well known that the concentrations of both substances are decreasing substantially with age, beginning at 50. According to that fact, they could become the markers of the aging process in human organism. Moreover low concentrations of DHEA and DHEAS are related to the evolution of many usual diseases contracted by older people, above all the diseases of cardiological, neurological, oncological, immunological system and osteoporosis. The influence of the hormones on the aspects above mentioned is present in this article and particularly the influence of DHEAS in the process of evolution the coronary artery disease.