Abstract
Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / physiology
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Candida albicans / genetics
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Candida albicans / immunology*
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Candidiasis / immunology
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Candidiasis / microbiology
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Cells, Cultured
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Crohn Disease / immunology
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Crohn Disease / microbiology
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Female
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Genotype
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / physiology*
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Leukocytes, Mononuclear / metabolism
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Nod1 Signaling Adaptor Protein
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Nod2 Signaling Adaptor Protein
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Toll-Like Receptor 2 / metabolism
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Toll-Like Receptor 4 / metabolism
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Transfection
Substances
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Adaptor Proteins, Signal Transducing
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Intracellular Signaling Peptides and Proteins
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NOD1 protein, human
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NOD2 protein, human
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Nod1 Signaling Adaptor Protein
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Nod2 Signaling Adaptor Protein
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Toll-Like Receptor 2
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Toll-Like Receptor 4