Charge migration in dicationic electrophiles and its application to the synthesis of aza-polycyclic aromatic compounds

Org Lett. 2006 Mar 16;8(6):1233-6. doi: 10.1021/ol060125u.

Abstract

[reaction: see text] Superacid-promoted reactions of dicationic electrophiles have been studied, and the positive charge centers are found to migrate apart in a predictable manner. Using isotopic labeling the charge migration is found in one system to occur through successive deprotonation-reprotonation steps. The charge migration chemistry is the basis for new general synthetic route to aza-polycyclic aromatic compounds.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aza Compounds / chemical synthesis*
  • Combinatorial Chemistry Techniques
  • Electrochemistry
  • Heterocyclic Compounds / chemical synthesis*
  • Molecular Structure
  • Polycyclic Aromatic Hydrocarbons / chemical synthesis*

Substances

  • Aza Compounds
  • Heterocyclic Compounds
  • Polycyclic Aromatic Hydrocarbons