Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions

Suzanne Hermeling; Wim Jiskoot; Daan J A Crommelin; Huub Schellekens

doi:10.1007/s11095-006-9573-5

Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions

Pharm Res. 2006 Mar;23(3):641-2; author reply 643-4. doi: 10.1007/s11095-006-9573-5. Epub 2006 Mar 15.

Authors

Suzanne Hermeling, Wim Jiskoot, Daan J A Crommelin, Huub Schellekens

PMID: 16525860
DOI: 10.1007/s11095-006-9573-5

Abstract

Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.

Publication types

Comment
Letter

MeSH terms

Chemistry, Pharmaceutical
Drug Storage
Epoetin Alfa
Erythropoietin / chemistry*
Hematinics / chemistry*
Micelles
Polysorbates / chemistry*
Recombinant Proteins
Surface-Active Agents / chemistry*
Syringes

Substances

Hematinics
Micelles
Polysorbates
Recombinant Proteins
Surface-Active Agents
Erythropoietin
Epoetin Alfa