Abstract
We report the first linezolid-resistant Staphylococcus aureus strain isolated in Brazil. The strain was isolated from a 10-year-old female patient with cystic fibrosis (CF) who received repeated and prolonged courses of low-dose linezolid. The strain belonged to the Brazilian endemic methicillin-resistant S. aureus clone, and the G2576U mutation was identified in domain V of the 23S rRNA. Detection of this mechanism of resistance in a CF patient is very worrisome, as these patients may become a reservoir for further dissemination of resistant strains. Our findings emphasise the importance of optimal dosage of linezolid to prevent the emergence of resistance.
MeSH terms
-
Acetamides / administration & dosage
-
Acetamides / pharmacology*
-
Acetamides / therapeutic use
-
Anti-Bacterial Agents / administration & dosage
-
Anti-Bacterial Agents / pharmacology
-
Anti-Bacterial Agents / therapeutic use
-
Brazil
-
Child
-
Cystic Fibrosis / complications*
-
Drug Resistance, Bacterial / genetics*
-
Female
-
Humans
-
Linezolid
-
Methicillin Resistance
-
Oxazolidinones / administration & dosage
-
Oxazolidinones / pharmacology*
-
Oxazolidinones / therapeutic use
-
Point Mutation
-
RNA, Ribosomal, 23S / genetics
-
Staphylococcal Infections / drug therapy
-
Staphylococcal Infections / microbiology*
-
Staphylococcus aureus / drug effects*
-
Staphylococcus aureus / isolation & purification
Substances
-
Acetamides
-
Anti-Bacterial Agents
-
Oxazolidinones
-
RNA, Ribosomal, 23S
-
Linezolid