Prodromal bullous pemphigoid

Int J Dermatol. 2006 Mar;45(3):209-14. doi: 10.1111/j.1365-4632.2004.02457.x.

Abstract

Background: Prodromal bullous pemphigoid (PBP) can be difficult to diagnose. Early recognition in its early stages may decrease the morbidity and progression of the disease. Clinical presentations and current treatments available for PBP will be described.

Methods: A retrospective review was performed on 53 patients diagnosed with PBP.

Results: Overall, the average disease duration of PBP was 11.8 months. The average age of presentation of PBP was 70.8 years. The most common presentations were urticaria-like plaques (67.9%), eczema-like lesions (11.3%), and dermatitis herpetiformis-like lesions (9.4%). The majority of patients responded well to low doses of systemic corticosteroids, tetracycline, and/or high potency topical corticosteroids.

Conclusions: Patients with PBP tend to be in their sixth or early seventh decade of life and, on average, the duration of disease is 1 year. The most common presentation of disease is urticaria-like plaques.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Cohort Studies
  • Complement C3
  • Doxycycline / therapeutic use
  • Fluorescent Antibody Technique, Direct
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulin G
  • Immunosuppressive Agents / therapeutic use
  • Middle Aged
  • Pemphigoid, Bullous / diagnosis*
  • Pemphigoid, Bullous / pathology
  • Pemphigoid, Bullous / therapy*
  • Retrospective Studies
  • Tetracycline / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Complement C3
  • Glucocorticoids
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Tetracycline
  • Doxycycline