Abstract
Hemoglobin-Vesicles (HbV; diameter, 250 nm) are artificial O2 carriers encapsulating purified and concentrated human Hb solution in phospholipid vesicles (liposomes), and their safety and efficacy, as a transfusion alternative, have been studied. In this paper, we summarized the characteristics of HbV that have been clarified by the microcirculatory observations.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Blood Substitutes / administration & dosage
-
Blood Substitutes / therapeutic use
-
Drug Carriers
-
Hemoglobins / administration & dosage
-
Hemoglobins / therapeutic use*
-
Humans
-
Liposomes*
-
Microcirculation / metabolism
-
Oxygen / metabolism*
-
Polyethylene Glycols / administration & dosage
-
Polyethylene Glycols / therapeutic use*
Substances
-
Blood Substitutes
-
Drug Carriers
-
Hemoglobins
-
Liposomes
-
PEG-hemoglobin
-
Polyethylene Glycols
-
Oxygen