Routine pelvic lymphadenectomy in apparently early stage endometrial cancer

Eur J Surg Oncol. 2006 May;32(4):450-4. doi: 10.1016/j.ejso.2006.02.008. Epub 2006 Mar 20.

Abstract

Aims: Controversial issues with respect to the treatment of patients with endometrial cancer include indications for lymphadenectomy and adjuvant radiotherapy.

Patient and methods: Between 1998 and 2004 all women with endometrial cancer stage I were included (n = 335). They all underwent total abdominal hysterectomy and bilateral salpingo-oöphorectomy. Two hundred and thirty-seven women also had a pelvic lymphadenectomy. When pelvic lymphadenectomy was performed, radiotherapy was administered only to patients with lymph-node metastases. Otherwise, adjuvant radiotherapy was based on the presence of risk factors.

Results: Eleven patients had lymph-node metastases. The overall absolute and relative survival-estimate at 5 years was 85.0 and 93.7%, respectively. Loco-regional recurrence was 8.5%. In the group with pelvic lymphadenectomy and negative lymph nodes these rates were 88.2, 93.9 and 5.6%, respectively. In 58 patients without any of the risk factors tumour grade III, deep myometrial invasion, or age > or =60 years, no lymph-node metastases were found.

Conclusion: In patients with endometrial cancer FIGO stage I without risk-factors, a phenomenon which occurs in about 25% of patients with clinical stage I endometrial cancer, a lymphadenectomy can be omitted. In other patients, the debate regarding the optimal treatment will remain.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Carcinoma / radiotherapy
  • Carcinoma / secondary
  • Carcinoma / surgery*
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / radiotherapy
  • Endometrial Neoplasms / surgery*
  • Female
  • Humans
  • Lymph Node Excision / methods*
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Staging
  • Pelvis
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome