After a brief overview of the most commonly discussed sellar approaches in literature, the authors focus on their "Two Nostrils Four Hands" technique. This approach allows otorhinolaryngologists and neurosurgeons to co-operate and its advantages are described. In the discussion the authors want to demonstrate how this collaboration can favour a true interdisciplinary improvement in the treatment of sellar pathology. They also want to demonstrate how this technique can be microinvasive with the use of the two nostrils at the same time, thus preserving the anatomical structures not involved.