A 14-year-old male milked the venom from a rattlesnake and injected it with a syringe into his right antecubital vein in a suicide attempt. He immediately developed severe pain and vomiting, then hypotension, swollen lips and tongue, and coma. The injection site did not have the considerable tissue damage seen with severe rattlesnake envenomation. Critical hematological abnormalities, gastrointestinal bleeding, and hematuria developed over 24 hours. He received crotalidae polyvalent immune fab (ovine) anti-venom and was discharged after 5 days without sequela. This patient's clinical findings were similar to those seen in patients bitten by rattlesnakes with rare intravenous envenomation.