Abstract
The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).
Publication types
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Cluster Headache / epidemiology*
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Cluster Headache / genetics*
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DNA Mutational Analysis
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Female
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Genetic Predisposition to Disease / epidemiology
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Genetic Predisposition to Disease / genetics
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Genetic Testing / methods*
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Genetic Variation / genetics
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Germany / epidemiology
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Humans
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Male
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Orexin Receptors
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Polymorphism, Genetic
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Polymorphism, Single Nucleotide / genetics
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Prevalence
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Receptors, G-Protein-Coupled
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Receptors, Neuropeptide / genetics*
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Risk Assessment / methods*
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Risk Factors
Substances
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Orexin Receptors
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Receptors, G-Protein-Coupled
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Receptors, Neuropeptide