Abstract
Peripheral neuropathies occur in 5% of patients with Non-Hodgkin Lymphoma and represent the effects of therapy, direct compression or nerve infiltration by tumor, or paraneoplastic effects. Multifocal motor neuropathy with conduction block (MMNCB) is a rare demyelinating disorder of unknown etiology characterized by progressive, distal, asymmetric weakness mostly of the upper limbs with minimal or no sensory loss. We report a patient, who developed MMNCB at the time of isolated CNS relapse from a diffuse large B-cell lymphoma. Marked neurological improvement was achieved using intravenous immunoglobulin treatment. To our knowledge, MMNCB has thus far not been described as part of the spectrum of lymphoma-related peripheral neuropathies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cyclophosphamide / administration & dosage
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Demyelinating Diseases / complications
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Demyelinating Diseases / physiopathology
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Female
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Head and Neck Neoplasms / pathology
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Immunologic Factors / therapeutic use
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Lymphoma, B-Cell / complications*
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Lymphoma, B-Cell / drug therapy
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Lymphoma, Large B-Cell, Diffuse / complications*
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Methotrexate / administration & dosage
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Middle Aged
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Motor Neuron Disease / complications*
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Motor Neuron Disease / physiopathology
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Neoplasm Recurrence, Local / pathology
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Nervous System Neoplasms / complications*
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Nervous System Neoplasms / drug therapy
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Neural Conduction
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Peripheral Nervous System Diseases / complications
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Peripheral Nervous System Diseases / physiopathology
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Scalp / pathology
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Skin Neoplasms / pathology
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Thiotepa / administration & dosage
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Vincristine / administration & dosage
Substances
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Immunoglobulins, Intravenous
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Immunologic Factors
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Vincristine
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Cyclophosphamide
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Thiotepa
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Methotrexate