Abstract
The edible thorny oyster, Spondylus varius (Mizuiri-shoujou), was found to suppress the carbon tetrachloride-induced increase in serum aspartate and alanine aminotransferase activities in mice. Significant suppressive effects on these enzyme activities were found in the fraction eluted with 75% ethanol from polystyrene gel in a dose-dependent manner. These results suggest that S. varius exerts a protective effect against liver injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine Transaminase / antagonists & inhibitors
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / antagonists & inhibitors
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Aspartate Aminotransferases / blood
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Carbon Tetrachloride / pharmacology*
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Chemical and Drug Induced Liver Injury*
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Food
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Hot Temperature*
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Liver / drug effects
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Liver / enzymology
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Liver / pathology
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Liver Diseases / pathology
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Liver Diseases / prevention & control*
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Mice
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Pectinidae / chemistry*
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Tissue Extracts / pharmacology*
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Water / chemistry*
Substances
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Tissue Extracts
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Water
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Carbon Tetrachloride
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Aspartate Aminotransferases
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Alanine Transaminase