Abstract
A series of ethyl 4-(2-aryloxyhexyloxy)benzoates was prepared and tested for their activity to induce precocious metamorphosis in larvae of the silkworm. Phenyl analog 5 showed activity comparable to that of the 6-methyl-3-pyridyl analog reported as a novel anti-JH agent. The activity of 5 could be fully counteracted by methoprene, a JH agonist. The ethoxycarbonyl group of 5 was essential for its activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoates / chemical synthesis*
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Benzoates / chemistry
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Benzoates / pharmacology*
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Bombyx / drug effects
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Bombyx / growth & development
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Bombyx / metabolism
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Juvenile Hormones / antagonists & inhibitors*
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Larva / drug effects
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Larva / growth & development
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Larva / metabolism
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Molecular Structure
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Oxidation-Reduction
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Structure-Activity Relationship
Substances
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Benzoates
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Juvenile Hormones