Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line

Brain Res Mol Brain Res. 1991 Jul;10(4):351-4. doi: 10.1016/0169-328x(91)90095-f.

Abstract

The effect of the neurotrophic factor nerve growth factor (NGF) on the expression of the beta-amyloid gene has been studied in the clonal nerve cell line PC12. The neuronal differentiation of PC12 cells in the presence of NGF was accompanied by a shift in the ratio of beta-amyloid precursor protein (APP) transcripts. In particular there was reduced expression of the transcript coding for the longest precursor form (APP770) and a concomitant increase in the shortest (APP695) transcript following NGF treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Base Sequence
  • Cell Differentiation / drug effects*
  • Molecular Sequence Data
  • Nerve Growth Factors / pharmacology*
  • Neurons / cytology*
  • Neurons / drug effects
  • Neurons / physiology
  • Oligodeoxyribonucleotides
  • PC12 Cells
  • RNA Splicing / drug effects*
  • RNA, Messenger / drug effects
  • RNA, Messenger / genetics*
  • Transcription, Genetic

Substances

  • Amyloid beta-Protein Precursor
  • Nerve Growth Factors
  • Oligodeoxyribonucleotides
  • RNA, Messenger