Structural complexity in ubiquitin recognition

Cell. 2006 Mar 24;124(6):1133-6. doi: 10.1016/j.cell.2006.03.009.

Abstract

Ubiquitinated proteins are sorted into distinct pathways via association with several classes of ubiquitin binding domain-containing proteins. A virtual explosion in the field of ubiquitin binding proteins has revealed several new classes and interactions with distinct surfaces on ubiquitin, providing a clearer understanding of how sorting of ubiquitinated proteins is achieved.

Publication types

  • Review

MeSH terms

  • Animals
  • Guanine Nucleotide Exchange Factors / chemistry
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Humans
  • Models, Molecular
  • Protein Binding
  • Protein Structure, Tertiary / physiology
  • Protein Transport
  • Signal Transduction / physiology*
  • Ubiquitin / chemistry
  • Ubiquitin / metabolism*

Substances

  • Guanine Nucleotide Exchange Factors
  • RABGEF1 protein, human
  • Ubiquitin