Abstract
Thyroid hormone-mediated positive cardiotropic effects are differently regulated between the atria and ventricles. This regulation is, at least in part, dependent on sarcoplasmic reticulum (SR) proteins. Sarcolipin, a homologue of phospholamban, has been recently identified as an atrium-specific SR protein. The expression of sarcolipin mRNA was significantly decreased in the atria of mice with hyperthyroidism and in 3,5,3'-triiodo-l-thyronine-treated neonatal rat atrial myocytes. Promoter activity and mRNA stability analyses revealed that thyroid hormone post-transcriptionally down regulated the expression of sarcolipin mRNA. The atrium-specific effect of thyroid hormone may occur in part through the regulation of atrial sarcolipin gene expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium-Binding Proteins / genetics
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Cell Line
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Down-Regulation / drug effects*
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Heart Atria / metabolism
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Hyperthyroidism / chemically induced
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Hyperthyroidism / metabolism*
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Hyperthyroidism / pathology
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Mice
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Muscle Proteins / biosynthesis*
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Muscle Proteins / genetics
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Myocardium / metabolism*
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Myocardium / pathology
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Myocytes, Cardiac / metabolism
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Promoter Regions, Genetic / genetics
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Proteolipids / biosynthesis*
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Proteolipids / genetics
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RNA Stability / drug effects
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RNA, Messenger / metabolism
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Rats
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Sequence Homology, Amino Acid
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Transcription, Genetic / drug effects
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Triiodothyronine / administration & dosage*
Substances
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Calcium-Binding Proteins
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Muscle Proteins
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Proteolipids
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RNA, Messenger
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phospholamban
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Triiodothyronine
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sarcolipin