Large conjugative plasmids from clinical strains of Salmonella enterica serovar virchow contain a class 2 integron in addition to class 1 integrons and several non-integron-associated drug resistance determinants

Antimicrob Agents Chemother. 2006 Apr;50(4):1603-7. doi: 10.1128/AAC.50.4.1603-1607.2006.

Abstract

Two large conjugative resistance (R) plasmids from clinical strains of Salmonella enterica serovar Virchow carried a class 2 integron with the 5' conserved sequence (5'CS)-dfrA1-sat1-aadA1-3'CS gene array, which is associated with defective Tn7 transposons. In addition, each contained a different class 1 integron (with 5'CS-aadA1-3'CS or 5'CS-sat-smr-aadA1-3'CS gene arrays) linked to Tn21-Tn9 sequences, and several non-integron-associated R determinants. An intact copy of Tn7 (including the class 2 integron) was present in the chromosome of each strain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Conjugation, Genetic*
  • DNA Transposable Elements
  • Drug Resistance, Bacterial / genetics
  • Humans
  • Integrons*
  • Molecular Sequence Data
  • Plasmids*
  • Salmonella enterica / genetics*

Substances

  • DNA Transposable Elements

Associated data

  • GENBANK/AM055748