Abstract
The effects of several nonsteroidal antiinflammatory drugs, used at concentrations achievable in synovial fluid, on human osteoarthritic (OA) cartilage metallo-protease activity in vitro was studied. Acetaminophen and ketoprofen had no effect; sodium salicylate, indomethacin, and diclofenac slightly decreased proteoglycanase activity. Piroxicam and tenoxicam suppressed proteoglycanase activity by 48.2% and 68.3%, respectively, and suppressed collagenase activity by 19.1% and 36.8%, respectively. Use of these NSAIDs may help to decrease cartilage catabolism in patients with OA.
MeSH terms
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Acetaminophen / pharmacology
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cartilage, Articular / enzymology*
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Diclofenac / pharmacology
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Endopeptidases / metabolism*
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Female
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Humans
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Indomethacin / pharmacology
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Ketoprofen / pharmacology
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Male
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Metalloendopeptidases*
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Microbial Collagenase / metabolism*
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Middle Aged
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Osteoarthritis, Hip / drug therapy*
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Osteoarthritis, Hip / enzymology*
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Piroxicam / analogs & derivatives
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Piroxicam / pharmacology
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Salicylates / pharmacology
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Salicylic Acid
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Salicylates
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Piroxicam
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Diclofenac
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Acetaminophen
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Ketoprofen
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Endopeptidases
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proteoglycan-degrading metalloendopeptidases
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Metalloendopeptidases
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Microbial Collagenase
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Salicylic Acid
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Indomethacin
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tenoxicam