Abstract
A primary extramedullary myeloid cell tumor (pEMT) of an inguinal lymph node was completely excised without subsequent anti-tumor therapy in a 6-year-old child. Clinical observation and monitoring of blood and bone marrow (BM) did not reveal any pathologic results before 32 months, when a precursor B lymphoblastic leukemia was diagnosed. Identical T-cell receptor gamma rearrangement in nodal pEMT and in precursor B lymphoblastic leukemia in BM indicates a clonal relationship of these two tumors.
2007 Wiley-Liss, Inc
MeSH terms
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Acute Disease
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Antigens, Neoplasm / biosynthesis
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / biosynthesis
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Bone Marrow / pathology
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Child
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Cytogenetic Analysis
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Female
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Flow Cytometry
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Follow-Up Studies
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Humans
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Immunophenotyping
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Neoplasms, Second Primary / diagnosis
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Neoplasms, Second Primary / immunology
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Neoplasms, Second Primary / therapy*
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Polymerase Chain Reaction / methods
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / immunology
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Receptors, Antigen, T-Cell, gamma-delta / biosynthesis
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Receptors, Antigen, T-Cell, gamma-delta / genetics
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Remission Induction
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Sarcoma, Myeloid / diagnosis
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Sarcoma, Myeloid / immunology
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Sarcoma, Myeloid / therapy*
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Time Factors
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Treatment Outcome
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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Receptors, Antigen, T-Cell, gamma-delta