DNA damage and repair in atherosclerosis

Melli Mahmoudi; John Mercer; Martin Bennett

doi:10.1016/j.cardiores.2006.03.002

DNA damage and repair in atherosclerosis

Cardiovasc Res. 2006 Jul 15;71(2):259-68. doi: 10.1016/j.cardiores.2006.03.002. Epub 2006 Mar 7.

Authors

Melli Mahmoudi¹, John Mercer, Martin Bennett

Affiliation

¹ Division of Cardiovascular Medicine, University of Cambridge, Box 110, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.

PMID: 16580654
DOI: 10.1016/j.cardiores.2006.03.002

Abstract

There is increasing evidence that human atherosclerosis is associated with damage to the DNA of both circulating cells, and cells of the vessel wall. Reactive oxygen species are the most likely agents inducing DNA damage in atherosclerosis. DNA damage produces a variety of responses, including cell senescence, apoptosis and DNA repair. This review summarises the evidence for DNA damage in atherosclerosis, the cellular responses to damage and the mechanisms of signalling DNA damage.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis
Atherosclerosis / metabolism*
Atherosclerosis / pathology
Cellular Senescence
DNA / metabolism*
DNA Damage*
DNA Repair*
Humans
Muscle, Smooth, Vascular / metabolism*
Muscle, Smooth, Vascular / pathology
Oxidative Stress
Reactive Oxygen Species / metabolism
Signal Transduction / physiology*

Substances

Reactive Oxygen Species
DNA