Actinic keratosis and capecitabine therapy

J Oncol Pharm Pract. 2005 Dec;11(4):151-3. doi: 10.1191/1078155205jp163cr.

Abstract

Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK). During treatment, an apparent toxic skin reaction occurs before dermal quiescence ensues. We report a case of a typical flare of AK in a woman treated with capecitabine for advanced breast cancer.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / adverse effects
  • Antimetabolites, Antineoplastic / therapeutic use
  • Breast Neoplasms / drug therapy
  • Capecitabine
  • Carcinoma, Ductal, Breast / drug therapy
  • Deoxycytidine / adverse effects
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / therapeutic use
  • Fatal Outcome
  • Female
  • Fluorouracil / analogs & derivatives
  • Humans
  • Keratosis / chemically induced*

Substances

  • Antimetabolites, Antineoplastic
  • Deoxycytidine
  • Capecitabine
  • Fluorouracil