Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions

J Oncol Pharm Pract. 2005 Dec;11(4):155-7. doi: 10.1191/1078155205jp164oa.

Abstract

Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / chemistry
  • Diethylhexyl Phthalate / chemistry*
  • Drug Contamination / prevention & control
  • Drug Packaging / methods*
  • Etoposide / administration & dosage
  • Etoposide / chemistry*
  • Infusions, Intravenous
  • Pharmaceutical Solutions / administration & dosage
  • Pharmaceutical Solutions / chemistry*
  • Polyvinyl Chloride / chemistry*
  • Solubility

Substances

  • Antineoplastic Agents, Phytogenic
  • Pharmaceutical Solutions
  • Etoposide
  • Polyvinyl Chloride
  • Diethylhexyl Phthalate