Prostate cancer incidence and nutrition are closely connected and show large food-related differences. Lowest cancer incidence in Asian countries is observed under low-calorie, soy-based food. Mediterranean nutrition has cancer protective components (fruit, vegetables, oil, seafood). The highest cancer incidence in the United States goes along with high-calorie food, red meat and fat ingestion. Changes in lifestyle and nutrition can influence the cancer risk. Dietary supplements and vitamins are in wide use and part of a complementary and alternative medicine.