Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

Deepak B Salunke; Dyavar S Ravi; Vandana S Pore; Debashis Mitra; Braja G Hazra

doi:10.1021/jm051114u

Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells

J Med Chem. 2006 Apr 20;49(8):2652-5. doi: 10.1021/jm051114u.

Authors

Deepak B Salunke¹, Dyavar S Ravi, Vandana S Pore, Debashis Mitra, Braja G Hazra

Affiliation

¹ Organic Chemistry Synthesis Division, National Chemical Laboratory, Pune 411 008, India.

PMID: 16610808
DOI: 10.1021/jm051114u

Abstract

Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes / drug effects
CD4-Positive T-Lymphocytes / virology*
Cell Line
Cells, Cultured
Cholic Acid / chemical synthesis
Cholic Acid / chemistry
Cholic Acid / pharmacology*
Giant Cells / drug effects*
Giant Cells / virology
HIV Infections / virology*
HIV-1 / drug effects*
HIV-1 / physiology
Humans
Molecular Structure
Stereoisomerism
Structure-Activity Relationship
Virus Replication / drug effects*
Virus Replication / physiology

Substances

Cholic Acid