Abstract
Novel anti-cancer treatments use knowledge about the underlying biology of the tumor to find suitable molecular targets. The recent years have seen great advances in understanding the biology of melanoma. In the current review we discuss the most promising molecular targets for melanoma and suggest possible strategies for overcoming resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Humans
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Melanoma / drug therapy*
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Melanoma / enzymology
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Melanoma / genetics
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Mutation
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NF-kappa B / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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Proteasome Endopeptidase Complex / metabolism
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Proto-Oncogene Proteins B-raf / genetics
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Proto-Oncogene Proteins c-akt / metabolism
Substances
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Antineoplastic Agents
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NF-kappa B
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Phosphatidylinositol 3-Kinases
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BRAF protein, human
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Proto-Oncogene Proteins B-raf
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Proto-Oncogene Proteins c-akt
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Proteasome Endopeptidase Complex