Spinal extramedullary anaplastic ependymoma with spinal and intracranial metastases

J Neurooncol. 2006 Aug;79(1):57-9. doi: 10.1007/s11060-005-9114-9. Epub 2006 Apr 14.

Abstract

We describe a 29-year-old woman who presented with progressive neck pain, sensory deficit and weakness in both arms. Magnetic resonance imaging (MRI) of the cervical spine revealed an extramedullary tumor with severe spinal cord compression. During surgery an intradural extramedullary tumor was found. Further imaging showed a second lumbar spinal tumor. Microscopy of both tumors showed that both tumors were anaplastic ependymomas, which almost never present as extramedullary tumors. Two years after surgery, an intracranial extracerebral metastasis was found, without evidence of spinal recurrence.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / secondary*
  • Cervical Vertebrae
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Ependymoma / metabolism
  • Ependymoma / pathology*
  • Ependymoma / physiopathology
  • Female
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / metabolism
  • Lumbar Vertebrae
  • Magnetic Resonance Imaging
  • S100 Proteins / metabolism
  • Spinal Cord Neoplasms / metabolism
  • Spinal Cord Neoplasms / pathology*
  • Spinal Cord Neoplasms / physiopathology

Substances

  • Ki-67 Antigen
  • S100 Proteins