Cerebral infarction after high-dose intravenous immunoglobulin therapy for Kawasaki disease

Yasunori Wada; Atsushi Kamei; Yukiharu Fujii; Ken Ishikawa; Shoichi Chida

doi:10.1016/j.jpeds.2005.10.027

Cerebral infarction after high-dose intravenous immunoglobulin therapy for Kawasaki disease

J Pediatr. 2006 Mar;148(3):399-400. doi: 10.1016/j.jpeds.2005.10.027.

Authors

Yasunori Wada¹, Atsushi Kamei, Yukiharu Fujii, Ken Ishikawa, Shoichi Chida

Affiliation

¹ Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Japan.

PMID: 16615977
DOI: 10.1016/j.jpeds.2005.10.027

Abstract

A 3-year-old boy with Kawasaki disease developed a cerebral infarction after high-dose intravenous immunoglobulin. Aspirin did not prevent the stroke. Based on the numerous reports of thrombosis due to high-dose immunoglobulin in older individuals, we conclude that it is necessary to be aware of this complication when treating children with Kawasaki disease.

Publication types

Case Reports

MeSH terms

Cerebral Infarction / chemically induced*
Child, Preschool
Dose-Response Relationship, Drug
Humans
Immunoglobulins, Intravenous / administration & dosage
Immunoglobulins, Intravenous / adverse effects*
Male
Mucocutaneous Lymph Node Syndrome / drug therapy*

Substances

Immunoglobulins, Intravenous