Abstract
In this report, we show that the Chlamydia trachomatis-specific CD8+ T cell antigen class I accessible protein-1 (Cap1) is expressed during the early stages of the C. trachomatis developmental cycle. We provide additional evidence suggesting that Cap1 may be important in early immune recognition of the organism. Understanding the temporal and spatial expression of CD8+ T cell antigens such as Cap1 may be beneficial in designing multisubunit vaccines to stimulate a vigorous immune response against C. trachomatis.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antigens, Bacterial / immunology*
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Bacterial Vaccines / immunology
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CD8-Positive T-Lymphocytes / immunology*
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Cell Line
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Chlamydia Infections / immunology
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Chlamydia Infections / microbiology
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Chlamydia Infections / prevention & control
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Chlamydia trachomatis / genetics
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Chlamydia trachomatis / immunology*
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Humans
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Interferon-gamma / metabolism*
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Membrane Proteins / metabolism*
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Polymerase Chain Reaction
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RNA, Bacterial / analysis
Substances
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Antigens, Bacterial
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Bacterial Vaccines
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Cap1 protein, Chlamydia trachomatis
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Membrane Proteins
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RNA, Bacterial
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Interferon-gamma