Leishmanicidal activity of Pycnoporus sanguineus

Phytother Res. 2006 Jun;20(6):497-9. doi: 10.1002/ptr.1890.

Abstract

In the search for antiparasite compounds from the Colombian flora, an active compound against Leishmania (Viannia) panamensis amastigotes was isolated from the fungi Pycnoporus sanguineus. The structural elucid-ation was achieved with spectroscopic methods ((1)H and (13)C NMR and MS). This compound was identified as ergosterol 5,8-endoperoxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / isolation & purification*
  • Ergosterol / analogs & derivatives*
  • Ergosterol / chemistry
  • Ergosterol / isolation & purification
  • Leishmania guyanensis*
  • Polyporaceae / chemistry*
  • Polyporaceae / growth & development

Substances

  • Antiprotozoal Agents
  • ergosterol-5,8-peroxide
  • Ergosterol