Fatty acids profile and antiinflammatory activity of Nonea setosa R. et S

Phytother Res. 2006 May;20(5):422-3. doi: 10.1002/ptr.1886.

Abstract

In order to verify the antiinflammatory properties of Nonea setosa R. et S. (Fam. Boraginaceae) and to identify the relevant active principles, aerial parts of this plant were extracted with increasing polarity solvents. The antiinflammatory activity was investigated by a bioassay-oriented fractionation using the inhibition of the croton oil-induced ear oedema in mice as an experimental model of inflammation. GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Boraginaceae*
  • Croton Oil
  • Edema / chemically induced
  • Edema / prevention & control*
  • Fatty Acids / chemistry
  • Gas Chromatography-Mass Spectrometry
  • Mice
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use

Substances

  • Anti-Inflammatory Agents
  • Fatty Acids
  • Plant Extracts
  • Croton Oil