The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system

Heidi Mulcahy; Julie O'Callaghan; Eoin P O'Grady; Claire Adams; Fergal O'Gara

doi:10.1128/IAI.74.5.3012-3015.2006

The posttranscriptional regulator RsmA plays a role in the interaction between Pseudomonas aeruginosa and human airway epithelial cells by positively regulating the type III secretion system

Infect Immun. 2006 May;74(5):3012-5. doi: 10.1128/IAI.74.5.3012-3015.2006.

Authors

Heidi Mulcahy¹, Julie O'Callaghan, Eoin P O'Grady, Claire Adams, Fergal O'Gara

Affiliation

¹ BIOMERIT Research Centre, Department of Microbiology, University College Cork, Cork, Ireland.

Abstract

Posttranscriptional regulation of certain virulence-related genes in Pseudomonas aeruginosa is brought about by RsmA, a small RNA-binding protein. During interaction with airway epithelial cells, RsmA promoted actin depolymerization, cytotoxicity, and anti-internalization of P. aeruginosa by positively regulating the virulence-associated type III secretion system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actins / metabolism
Bacterial Proteins / physiology*
Bronchi / microbiology*
Cell Line
Drug Resistance, Bacterial
Epithelial Cells / microbiology
Humans
Pseudomonas aeruginosa / drug effects
Pseudomonas aeruginosa / metabolism*
RNA-Binding Proteins / physiology*

Substances

Actins
Bacterial Proteins
RNA-Binding Proteins