Today's urologists often face the dilemma of how to treat patients who have advancing prostate cancer. The diversity of this patient population makes treatment decisions challenging. For over 60 years the mainstay of treatment for patients who have advancing prostate cancer has been androgen deprivation therapy. Now there are new chemotherapeutic options, novel hormone manipulations, and other adjunctive therapies available. Based on a case presentation, the authors have attempted to outline for the practicing urologist, a logical progression of treatment options for advancing prostate cancer.