Abstract
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
MeSH terms
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Cell Differentiation / physiology
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Cell Division / physiology*
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Hematopoietic Stem Cells / cytology*
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Hematopoietic Stem Cells / physiology
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Humans
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Nuclear Proteins / genetics*
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Nuclear Proteins / physiology*
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Polycomb Repressive Complex 1
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins / physiology*
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Repressor Proteins / genetics*
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Repressor Proteins / physiology*
Substances
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BMI1 protein, human
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Nuclear Proteins
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Proto-Oncogene Proteins
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Repressor Proteins
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Polycomb Repressive Complex 1