Abstract
Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles*
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Animals
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Antimalarials / therapeutic use*
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Artemether, Lumefantrine Drug Combination
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Artemisinins / therapeutic use
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Drug Combinations
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Drug Therapy, Combination
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Endemic Diseases*
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Ethanolamines
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Fluorenes / therapeutic use
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Genes, MDR*
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Humans
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / epidemiology*
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Malaria, Falciparum / parasitology
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / genetics
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Polymorphism, Genetic
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Prevalence
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Selection, Genetic*
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Sesquiterpenes / therapeutic use
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Uganda / epidemiology
Substances
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Antimalarials
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Artemether, Lumefantrine Drug Combination
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Artemisinins
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Drug Combinations
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Ethanolamines
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Fluorenes
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Sesquiterpenes