Genetic variations of the Plasmodium vivax dihydropteroate synthase gene

Michela Menegon; Giancarlo Majori; Carlo Severini

doi:10.1016/j.actatropica.2006.03.003

Genetic variations of the Plasmodium vivax dihydropteroate synthase gene

Acta Trop. 2006 May;98(2):196-9. doi: 10.1016/j.actatropica.2006.03.003. Epub 2006 May 2.

Authors

Michela Menegon¹, Giancarlo Majori, Carlo Severini

Affiliation

¹ Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy. [email protected]

PMID: 16647679
DOI: 10.1016/j.actatropica.2006.03.003

Abstract

Dihydropteroate synthase gene of Plasmodium vivax was recently identified. In the present study, the sequences of the dyhydropteroate synthase gene of 68 P. vivax isolates from various geographic areas were compared. Sequencing revealed limited polymorphism at codons 383 and 553 in all analyzed samples. Interstrain analysis showed several genotypic variations in the tandem repeats domain which produce length polymorphism between different parasite isolates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
DNA, Protozoan / genetics
Dihydropteroate Synthase / genetics*
Drug Resistance / genetics
Genetic Variation
Genotype
Humans
Malaria, Vivax / drug therapy*
Molecular Sequence Data
Plasmodium vivax / enzymology*
Plasmodium vivax / genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Sequence Analysis, DNA

Substances

DNA, Protozoan
Dihydropteroate Synthase